HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.928

Property	Details
Experiments	25814554, 11071635, 9822717, 11553620, unassigned1126
Identification Methods	two hybrid, pull down, affinity chromatography technology, far western blotting, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 481
+	Hs
		802714 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		581044 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		557780 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		548746 VAV_HUMAN (214-293): 3.43e-15: 77.9: 30.86		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		956524 NCK1_MOUSE (85-196): 3.75e-16: 79.8: 22.81		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Hs
		235054 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		151734 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		802639 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		DOK3_HUMAN (1-458): 6.22e-116: 351: 31.21
+	Hs
		235053 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		151733 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		235042 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Mm
		724603 CRK_MOUSE (3-302): 5.71e-54: 180: 55.21		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Mm
		250957 NCK1_MOUSE (85-196): 3.75e-16: 79.8: 22.81		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		151706 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		235041 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		562631 PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Hs
		802675 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09
+	Hs
		581086 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Dm
		993227 GRAP_DROME (126-293): 1.68e-23: 97.6: 17.79		IRS1_DROME (26-343): 3.54e-69: 239: 15.03
+	Hs
		207363 SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69		FRS3_HUMAN (153-432): 4e-52: 185: 20.42