HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 0.60 0.595

The method score is based on:

Property Details
Experiments 28351972, 10077672
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0001947 - heart looping
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 8 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 2555
Hs

1 467
+ Mm
+ Mm
+ Mm
+ Mm
+ Hs
+ Mm
+ Mm
+ Mm
+ Mm
+ Mm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024