HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: RAB5C (P51148)
Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Gene: RAB5C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Ras, Ank_2~Ras, Ank_4~Ras
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2555 Hs			1 216
+	Hs
		592146 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57
+	Hs
		804192 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25
+	Hs
		257589 ANR17_HUMAN (1919-2553): 8.85e-80: 297: 13.87		RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00
+	Hs
		844802 JAG2_HUMAN (1096-1581): 9.02e-42: 171: 22.92		RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00
+	Hs
		592587 JAG2_HUMAN (1096-1581): 9.02e-42: 171: 22.92		RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57
+	Hs
		844493 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00
+	Hs
		592217 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		RAB5A_HUMAN (1-216): 1.03e-89: 264: 86.57
+	Hs
		914022 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25