HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Ras, Ank_2~Ras, Ank_4~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010008 - endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2555 Hs			1 196
+	Hs
		804195 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		804189 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		545253 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436195 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		804203 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		804186 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		804187 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		564446 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120337 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		925204 ANK2_HUMAN (1662-2151): 4.82e-101: 367: 16.67		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		925238 ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		900423 ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915638 ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		950953 ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		893947 ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		120412 ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		916082 JAG2_HUMAN (1096-1581): 9.02e-42: 171: 22.92		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		545315 JAG1_HUMAN (8-429): 2.99e-40: 166: 25.26		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436252 JAG1_HUMAN (8-429): 2.99e-40: 166: 25.26		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		120719 JAG2_HUMAN (1096-1581): 9.02e-42: 171: 22.92		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98