HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: JAG1 (P78504)
Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)
Gene: JAG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.899

The method score is based on:

Property Details
Experiments 11006133, 21820430, 18660822, 23086448
Identification Methods pull down, affinity chromatography technology, surface plasmon resonance, nuclear magnetic resonance, enzyme linked immunosorbent assay
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EGF~EGF, EGF~EGF_CA, DSL~EGF_CA, EGF_CA~EGF_CA, EGF_CA~MNNL
Common GO terms GO:0002085 - inhibition of neuroepithelial cell differentiation
GO:0003180 - aortic valve morphogenesis
GO:0003184 - pulmonary valve morphogenesis
GO:0005112 - Notch binding
GO:0005509 - calcium ion binding
and 15 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024