HitPredict - High confidence protein-protein interactions

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: SUH (Q06330)
Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)
Gene: RBPJ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.993

Property	Details
Experiments	26033182, 26186194, 26496610, 25609649, 28514442, 19321451, 33961781, 9111040, 22888005, 36129980, 11511084, 19800882, 17636029, 21820430, 23103515, 11997524, 17573339, 12644465, 30975888, 30967258 and 11 others more... 16682003, 20118921, 22100894, 17526737, 23022380, 11390662, 22325781, 19907488, 17284587, 10713164, 21475249
Identification Methods	affinity chromatography technology, pull down, mass spectrometry study of hydrogen/deuterium exchange, surface plasmon resonance, molecular sieving, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Ank_2~BTD, Ank_2~LAG1-DNAbind, Ank_2~TIG_SUH
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001837 - epithelial to mesenchymal transition GO:0002193 - MAML1-RBP-Jkappa- ICN1 complex GO:0002437 - inflammatory response to antigenic stimulus and 27 others more... GO:0003151 - outflow tract morphogenesis GO:0003160 - endocardium morphogenesis GO:0003198 - epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003214 - cardiac left ventricle morphogenesis GO:0003222 - ventricular trabecula myocardium morphogenesis GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0006959 - humoral immune response GO:0007219 - Notch signaling pathway GO:0007221 - positive regulation of transcription of Notch receptor target GO:0007507 - heart development GO:0009912 - auditory receptor cell fate commitment GO:0009957 - epidermal cell fate specification GO:0010628 - positive regulation of gene expression GO:0030216 - keratinocyte differentiation GO:0030279 - negative regulation of ossification GO:0030513 - positive regulation of BMP signaling pathway GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050673 - epithelial cell proliferation GO:0050679 - positive regulation of epithelial cell proliferation GO:0060045 - positive regulation of cardiac muscle cell proliferation GO:0060379 - cardiac muscle cell myoblast differentiation GO:0060412 - ventricular septum morphogenesis GO:0061344 - regulation of cell adhesion involved in heart morphogenesis GO:0120163 - negative regulation of cold-induced thermogenesis
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	2555
Hs

1	500

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024