HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: SNW1 (Q13573)
SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)
Gene: SNW1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.697

The method score is based on:

Property	Details
Experiments	11404076, 10713164, 17573339, 15546612
Identification Methods	two hybrid, affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003713 - transcription coactivator activity GO:0005112 - Notch binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 4 others more... GO:0006357 - regulation of transcription by RNA polymerase II GO:0019899 - enzyme binding GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	2555
Hs

1	536

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024