HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: STK38 (Q15208)
Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)
Gene: STK38

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35508987, 23022380
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2555 Hs			1 465
+	Hs
		804352 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		LATS2_HUMAN (5-465): 2.49e-150: 457: 40.58
+	Hs
		681729 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		AKT1_HUMAN (36-447): 7.66e-138: 406: 27.06
+	Hs
		804235 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		ROCK1_HUMAN (70-415): 3.59e-79: 270: 42.90
+	Hs
		325811 ANR52_HUMAN (1998-2492): 2.36e-64: 242: 13.80		LATS1_HUMAN (7-448): 7.81e-146: 446: 40.48
+	Hs
		325632 TENA_HUMAN (1356-1565): 3.2e-18: 94.5: 20.94		LATS1_HUMAN (7-448): 7.81e-146: 446: 40.48
+	Hs
		980549 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		LATS2_HUMAN (5-465): 2.49e-150: 457: 40.58
+	Hs
		325700 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		LATS1_HUMAN (7-448): 7.81e-146: 446: 40.48