HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: DTX1 (Q86Y01)
E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1)
Gene: DTX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	17573339, 11564735, 20208568
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005112 - Notch binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006366 - transcription by RNA polymerase II and 1 others more... GO:0007219 - Notch signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2555 Hs			1 620
+	Hs
		804279 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		DTX2_HUMAN (9-615): 0: 830: 45.66
+	Hs
		804381 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		DTX4_HUMAN (23-615): 0: 795: 63.89
+	Hs
		1200375 NOTC3_HUMAN (1-2014): 0: 679: 27.54		DTX2_HUMAN (9-615): 0: 830: 45.66
+	Hs
		980431 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		DTX2_HUMAN (9-615): 0: 830: 45.66
+	Hs
		980467 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		DTX3L_HUMAN (341-613): 9.99e-114: 358: 34.41
+	Dm
		422749 NOTCH_DROME (1984-2545): 4.18e-12: 74.6: 12.78		DTX_DROME (12-230): 7.31e-81: 271: 27.71
+	Hs
		980453 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		DTX3_HUMAN (408-615): 6.4e-84: 268: 34.91