Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1
Interactor 2: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 0.60 | 0.767 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 27806347, 28459460, 27229929, 32041737, 32792479, 11425854, 17646408, 35508987, 17646409, 17526737, 21820430, 23022380, 26033182, 26108681, 27247421, 30510140, 31152129, 31285543, 33086033, 22388891 and 4 others
more... |
| Identification Methods | affinity chromatography technology, pull down, protein complementation assay, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification, split luciferase complementation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007219 - Notch signaling pathway GO:0010629 - negative regulation of gene expression and 2 others more... |
| Homologous interactions | 10 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
