Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: MAML3 (Q96JK9)
Mastermind-like protein 3 (Mam-3)
Gene: MAML3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.826

The method score is based on:

Property Details
Experiments 12370315, 23022380
Identification Methods two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~MamL-1
Common GO terms GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0007219 - Notch signaling pathway
GO:0007221 - positive regulation of transcription of Notch receptor target
and 1 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 2555
Hs

1 1138
+ Hs
+ Mm
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024