HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: EGFL7 (Q9UHF1)
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
Gene: EGFL7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	19503073
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	EGF~FXa_inhibition, EGF_CA~FXa_inhibition
Common GO terms	GO:0005509 - calcium ion binding GO:0005576 - extracellular region GO:0009986 - cell surface
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2555 Hs			1 273
+	Mm
		966335 NOTC1_MOUSE (24-2555): 0: 1363: 90.53		EGFL7_MOUSE (1-272): 1.11e-36: 133: 78.10
+	Hs
		804198 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		JAG1_HUMAN (66-168): 1.68e-10: 63.2: 28.57
+	Hs
		804163 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		1355435 NOTC3_HUMAN (1-2014): 0: 679: 27.54		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Hs
		944134 NOTC3_HUMAN (1-2014): 0: 679: 27.54		JAG1_HUMAN (66-168): 1.68e-10: 63.2: 28.57
+	Hs
		804372 NOTC3_HUMAN (1-2014): 0: 679: 27.54		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Dm
		65546 A8JNM5_DROME (1677-2536): 7.87e-130: 462: 14.56		NOTCH_DROME (68-172): 9.27e-10: 61: 22.32
+	Dm
		246781 Q0KIE7_DROME (1783-2507): 6.09e-116: 408: 13.99		TENM_DROME (4-250): 1.41e-23: 102: 12.37
+	Mm
		1143214 NOTC3_MOUSE (1-798): 2.52e-83: 308: 30.06		EGFL7_MOUSE (1-272): 1.11e-36: 133: 78.10
+	Hs
		1303971 NOTC4_HUMAN (818-1672): 4.31e-79: 294: 25.00		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Hs
		804293 ANR44_HUMAN (1554-2093): 7.06e-68: 252: 15.72		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Dm
		90684 E1JHA6_DROME (6-297): 5.95e-51: 202: 33.22		NOTCH_DROME (68-172): 9.27e-10: 61: 22.32
+	Hs
		804379 JAG2_HUMAN (1096-1581): 9.02e-42: 171: 22.92		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Dm
		246722 SERR_DROME (1171-1583): 1.68e-28: 128: 22.03		TENM_DROME (4-250): 1.41e-23: 102: 12.37
+	Dr
		60071 A4JYS0_DANRE (1133-1427): 7.81e-33: 140: 33.78		A4JYS0_DANRE (41-186): 6.71e-16: 79.1: 23.18
+	Dm
		422718 SERR_DROME (1171-1583): 1.68e-28: 128: 22.03		NOTCH_DROME (68-172): 9.27e-10: 61: 22.32
+	Hs
		1059111 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		FBLN5_HUMAN (13-187): 8.52e-09: 57.5: 17.46
+	Mm
		966325 DLL1_MOUSE (31-226): 5.33e-24: 112: 37.88		NOTC1_MOUSE (85-189): 5.56e-09: 58.6: 27.03
+	Hs
		132252 DLL1_HUMAN (31-226): 1.8e-23: 110: 37.37		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81