HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: IKZF2 (Q9UKS7)
Zinc finger protein Helios (Ikaros family zinc finger protein 2)
Gene: IKZF2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23022380
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2555 Hs			1 526
+	Hs
		804234 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20
+	Hs
		804369 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52
+	Hs
		264763 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZN254_HUMAN (3-464): 5.31e-172: 502: 16.42
+	Hs
		1059113 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZN107_HUMAN (82-523): 5.36e-154: 460: 18.53
+	Hs
		1059110 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZN624_HUMAN (3-323): 6.9e-132: 405: 20.36
+	Hs
		477789 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		ZN888_HUMAN (3-344): 1.29e-124: 382: 18.01
+	Hs
		67868 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZN724_HUMAN (8-254): 4.02e-90: 290: 23.29
+	Hs
		1059088 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZN480_HUMAN (4-299): 5.91e-88: 282: 21.75
+	Hs
		1219780 ANKH1_HUMAN (1617-2544): 8.61e-80: 297: 12.51		ZNF34_HUMAN (165-517): 5.65e-19: 92.1: 14.70
+	Hs
		67863 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		ZN724_HUMAN (8-254): 4.02e-90: 290: 23.29
+	Hs
		1059085 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZN431_HUMAN (107-505): 2.37e-53: 191: 18.54
+	Hs
		1059105 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZN430_HUMAN (120-504): 7.71e-47: 173: 17.42
+	Hs
		563253 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZNF12_HUMAN (248-525): 4.62e-42: 161: 14.54
+	Hs
		275736 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		ZN189_HUMAN (368-526): 3.12e-43: 164: 15.53
+	Hs
		1059084 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZN398_HUMAN (112-220): 1.59e-21: 100: 41.28
+	Hs
		62497 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZN316_HUMAN (113-188): 1.13e-10: 66.2: 40.79
+	Hs
		977955 LTBP2_HUMAN (4-596): 1.9e-24: 115: 20.27		ZNF92_HUMAN (113-215): 3.94e-09: 61.2: 31.07
+	Hs
		563858 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		ZNF32_HUMAN (113-214): 2.1e-15: 78.6: 37.26
+	Hs
		62488 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		ZN316_HUMAN (113-188): 1.13e-10: 66.2: 40.79
+	Hs
		977952 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		ZNF92_HUMAN (113-215): 3.94e-09: 61.2: 31.07