HitPredict

Interactor 1: UBC4 (P46595)
Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4)
Gene: UBC4

Interactor 2: APC11 (Q9UT86)
Anaphase-promoting complex subunit 11 (20S cyclosome/APC complex protein apc11)
Gene: APC11

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21389117
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-ANAPC11
Common GO terms	GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0045842 - positive regulation of mitotic metaphase/anaphase transition
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Sp			1 94
+	Sc
		549847 UBC4_YEAST (3-147): 1.31e-79: 233: 83.45		APC11_YEAST (1-85): 6.24e-33: 113: 45.10
+	Ce
		715108 UBC2_CAEEL (1-147): 2.67e-82: 239: 85.71		APC11_CAEEL (1-85): 1.88e-30: 106: 40.23
+	Hs
		849463 UB2D1_HUMAN (1-147): 1.88e-82: 240: 79.59		APC11_HUMAN (1-85): 1.32e-30: 105: 50.59
+	Hs
		919882 UB2D2_HUMAN (1-147): 3.47e-82: 239: 84.35		APC11_HUMAN (1-85): 1.32e-30: 105: 50.59
+	Hs
		921482 UB2D4_HUMAN (1-147): 2.47e-83: 242: 83.67		RBX1_HUMAN (2-85): 8.51e-29: 101: 31.46
+	Hs
		895932 UB2D3_HUMAN (1-147): 3.92e-81: 237: 84.35		APC11_HUMAN (1-85): 1.32e-30: 105: 50.59
+	Hs
		849303 UB2D1_HUMAN (1-147): 1.88e-82: 240: 79.59		RBX1_HUMAN (2-85): 8.51e-29: 101: 31.46
+	Mm
		895979 UB2D1_MOUSE (1-147): 1.88e-82: 240: 79.59		RBX1_MOUSE (2-85): 8.51e-29: 101: 31.46
+	Hs
		919703 UB2D2_HUMAN (1-147): 3.47e-82: 239: 84.35		RBX1_HUMAN (2-85): 8.51e-29: 101: 31.46
+	Mm
		919923 UB2D2_MOUSE (1-147): 3.47e-82: 239: 84.35		RBX1_MOUSE (2-85): 8.51e-29: 101: 31.46
+	Hs
		895771 UB2D3_HUMAN (1-147): 3.92e-81: 237: 84.35		RBX1_HUMAN (2-85): 8.51e-29: 101: 31.46
+	Mm
		895973 UB2D3_MOUSE (1-147): 3.92e-81: 237: 84.35		RBX1_MOUSE (2-85): 8.51e-29: 101: 31.46
+	Ce
		715111 UBC2_CAEEL (1-147): 2.67e-82: 239: 85.71		RBX1_CAEEL (2-85): 1.6e-27: 98.3: 32.58
+	Hs
		1354003 UB2D4_HUMAN (1-147): 2.47e-83: 242: 83.67		RBX2_HUMAN (3-85): 7.9e-24: 88.7: 32.94
+	Hs
		849472 UB2D1_HUMAN (1-147): 1.88e-82: 240: 79.59		RBX2_HUMAN (3-85): 7.9e-24: 88.7: 32.94
+	Hs
		919890 UB2D2_HUMAN (1-147): 3.47e-82: 239: 84.35		RBX2_HUMAN (3-85): 7.9e-24: 88.7: 32.94
+	Sc
		549843 UBC4_YEAST (3-147): 1.31e-79: 233: 83.45		RBX1_YEAST (2-85): 7.08e-26: 94.4: 33.71
+	Hs
		895936 UB2D3_HUMAN (1-147): 3.92e-81: 237: 84.35		RBX2_HUMAN (3-85): 7.9e-24: 88.7: 32.94
+	Hs
		296887 UB2D1_HUMAN (1-147): 1.88e-82: 240: 79.59		LTN1_HUMAN (10-81): 2.52e-13: 65.5: 26.32
+	Hs
		296893 UB2D2_HUMAN (1-147): 3.47e-82: 239: 84.35		LTN1_HUMAN (10-81): 2.52e-13: 65.5: 26.32