HitPredict

Interactor 1: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Interactor 2: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.901

The method score is based on:

Property Details
Experiments 28205554, 31980649, 9162092, 7839144
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology, enzymatic study, in-gel kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000165 - MAPK cascade
GO:0001817 - regulation of cytokine production
GO:0002931 - response to ischemia
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
and 25 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 347
Hs

1 347
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Last updated: 15 Jul 2024