HitPredict

Interactor 1: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Interactor 2: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	16709866
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 347 Hs			1 418
+	Hs
		681739 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Mm
		682118 AKT1_MOUSE (36-345): 5.46e-128: 376: 20.76		ARRB1_MOUSE (1-418): 0: 703: 98.57
+	Hs
		800970 MP2K4_HUMAN (1-345): 1.56e-114: 339: 47.80		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		681683 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		682136 AKT2_HUMAN (38-345): 6.46e-126: 371: 22.79		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Mm
		682122 AKT1_MOUSE (36-345): 5.46e-128: 376: 20.76		ARRB2_MOUSE (1-407): 0: 615: 75.00
+	Hs
		685834 MP2K4_HUMAN (1-345): 1.56e-114: 339: 47.80		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		153095 MP2K7_HUMAN (49-345): 3.41e-108: 324: 43.81		ARRC_HUMAN (6-408): 0: 561: 57.43
+	Hs
		685915 MP2K1_HUMAN (49-344): 5.25e-65: 212: 36.69		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Dm
		1097532 DSOR1_DROME (47-339): 1.96e-61: 203: 37.62		Q9V393_DROME (4-402): 0: 576: 59.86