HitPredict

Interactor 1: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Interactor 2: DCTN1 (Q14203)
Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Gene: DCTN1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	15375157
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 347 Hs			1 1278
+	Hs
		681840 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		1051339 MARK2_HUMAN (8-344): 2.1e-119: 364: 20.41		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		854726 MP2K6_HUMAN (12-345): 3.22e-121: 354: 79.04		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		681975 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		CLIP3_HUMAN (10-139): 7.2e-31: 131: 31.34
+	Hs
		1183134 MARK2_HUMAN (8-344): 2.1e-119: 364: 20.41		KI13B_HUMAN (14-145): 4.98e-32: 138: 32.85
+	Hs
		682199 AKT2_HUMAN (38-345): 6.46e-126: 371: 22.79		CLIP3_HUMAN (10-139): 7.2e-31: 131: 31.34
+	Mm
		82707 AKT1_MOUSE (36-345): 5.46e-128: 376: 20.76		CLIP3_MOUSE (29-139): 1.07e-27: 121: 34.51
+	Mm
		82708 AKT2_MOUSE (38-345): 1.45e-124: 367: 22.79		CLIP3_MOUSE (29-139): 1.07e-27: 121: 34.51
+	Mm
		554927 KPCE_MOUSE (3-344): 1.79e-119: 363: 19.32		MYH7_MOUSE (64-763): 5.3e-27: 122: 9.66
+	Hs
		528363 MP2K3_HUMAN (1-347): 1.73e-124: 362: 100.00		MYH6_HUMAN (47-712): 5.82e-26: 118: 9.71
+	Hs
		681696 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		551616 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		DESP_HUMAN (227-1049): 1.36e-14: 81.5: 14.64
+	Hs
		724784 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		625177 CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		551672 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		DESP_HUMAN (227-1049): 1.36e-14: 81.5: 14.64
+	Mm
		554901 KPCE_MOUSE (3-344): 1.79e-119: 363: 19.32		MYH6_MOUSE (830-1276): 2.24e-14: 80.6: 10.06
+	Hs
		625176 CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		551610 CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43		DESP_HUMAN (227-1049): 1.36e-14: 81.5: 14.64
+	Hs
		528401 CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43		MYH8_HUMAN (62-436): 3.47e-11: 70.2: 11.05
+	Hs
		502911 STK4_HUMAN (42-345): 1.62e-103: 314: 33.12		MYH3_HUMAN (830-1278): 8.46e-13: 75.6: 10.11