HitPredict

Interactor 1: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Interactor 2: TBA1C (Q9BQE3)
Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]
Gene: TUBA1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 347 Hs			1 449
+	Hs
		969108 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		TBA1C_HUMAN (1-449): 0: 733: 100.00
+	Hs
		681913 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		TBA1A_HUMAN (1-439): 0: 715: 99.09
+	Hs
		933175 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		TBA1B_HUMAN (1-439): 0: 717: 99.09
+	Hs
		805386 MP2K3_HUMAN (1-347): 1.73e-124: 362: 100.00		TBA1B_HUMAN (1-439): 0: 717: 99.09
+	Hs
		428041 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		681781 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		625584 CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43		TBA1C_HUMAN (1-449): 0: 733: 100.00
+	Hs
		428148 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		428081 MP2K3_HUMAN (1-347): 1.73e-124: 362: 100.00		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		933762 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		805387 MP2K3_HUMAN (1-347): 1.73e-124: 362: 100.00		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		1023101 STK4_HUMAN (42-345): 1.62e-103: 314: 33.12		TBA1C_HUMAN (1-449): 0: 733: 100.00
+	Hs
		933421 STK4_HUMAN (42-345): 1.62e-103: 314: 33.12		TBA4A_HUMAN (1-448): 0: 724: 96.21
+	Hs
		625344 CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		160742 AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70		TBA1C_HUMAN (1-449): 0: 733: 100.00
+	Hs
		933777 STK4_HUMAN (42-345): 1.62e-103: 314: 33.12		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Ce
		110168 GCK1_CAEEL (64-330): 2.13e-98: 306: 30.97		O18688_CAEEL (1-439): 0: 699: 87.70
+	Hs
		160334 AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70		TBB5_HUMAN (1-439): 0: 699: 41.00
+	Hs
		160504 AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70		TBB4B_HUMAN (1-437): 0: 697: 40.73
+	Hs
		428177 MP2K5_HUMAN (56-324): 7.89e-66: 216: 45.09		TBB5_HUMAN (1-439): 0: 699: 41.00