HitPredict

Interactor 1: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Interactor 2: RASF1 (Q9NS23)
Ras association domain-containing protein 1
Gene: RASSF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	28205554, 28628118
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Pkinase, Nore1-SARAH~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 347 Hs			1 344
+	Hs
		682035 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		RASF1_HUMAN (1-344): 7.96e-150: 427: 100.00
+	Hs
		854744 MP2K6_HUMAN (12-345): 3.22e-121: 354: 79.04		RASF1_HUMAN (1-344): 7.96e-150: 427: 100.00
+	Hs
		681802 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Mm
		682107 AKT1_MOUSE (36-345): 5.46e-128: 376: 20.76		KPCZ_MOUSE (15-152): 4.36e-33: 131: 24.11
+	Hs
		682169 AKT2_HUMAN (38-345): 6.46e-126: 371: 22.79		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		566359 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		KPCA_HUMAN (24-266): 3.82e-36: 140: 12.74
+	Hs
		983943 AKT3_HUMAN (24-345): 1.36e-125: 370: 20.91		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		566289 KPCL_HUMAN (22-344): 3.41e-119: 360: 19.58		KPCA_HUMAN (24-266): 3.82e-36: 140: 12.74
+	Hs
		969095 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		GRP3_HUMAN (48-215): 1.37e-34: 135: 20.81
+	Hs
		623873 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		KPCL_HUMAN (51-289): 3.04e-34: 134: 17.77
+	Hs
		623868 MP2K3_HUMAN (1-347): 1.73e-124: 362: 100.00		KPCL_HUMAN (51-289): 3.04e-34: 134: 17.77
+	Hs
		1068473 MARK2_HUMAN (8-344): 2.1e-119: 364: 20.41		KPCD1_HUMAN (50-183): 2.44e-19: 91: 19.40
+	Hs
		969083 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		KPCD1_HUMAN (50-183): 2.44e-19: 91: 19.40
+	Mm
		554867 AKT1_MOUSE (36-345): 5.46e-128: 376: 20.76		KPCE_MOUSE (27-107): 4.01e-13: 72.2: 31.33
+	Hs
		681803 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		KPCD_HUMAN (23-114): 2.53e-12: 69.9: 21.74
+	Hs
		681799 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		KPCT_HUMAN (30-114): 9.76e-11: 64.9: 27.06
+	Hs
		969093 MARK2_HUMAN (8-344): 2.1e-119: 364: 20.41		KPCE_HUMAN (27-107): 4.59e-13: 72.2: 31.33
+	Hs
		969068 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		KPCE_HUMAN (27-107): 4.59e-13: 72.2: 31.33
+	Hs
		647878 MARK3_HUMAN (8-344): 6.23e-120: 364: 19.53		KPCT_HUMAN (30-114): 9.76e-11: 64.9: 27.06