HitPredict

Interactor 1: BRCC3 (P46736)
Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)
Gene: BRCC3

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29656893, 22990118
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 316 Hs			1 2089
+	Hs
		1056913 CSN5_HUMAN (13-228): 6.32e-67: 214: 20.64		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		805525 BRCC3_HUMAN (13-316): 6.26e-139: 397: 100.00		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		805539 BRCC3_HUMAN (13-316): 6.26e-139: 397: 100.00		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Hs
		130868 PSDE_HUMAN (6-309): 7.58e-75: 234: 21.47		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		1019055 CSN5_HUMAN (13-228): 6.32e-67: 214: 20.64		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		1264776 CSN5_HUMAN (13-228): 6.32e-67: 214: 20.64		TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72
+	Hs
		1272707 CSN5_HUMAN (13-228): 6.32e-67: 214: 20.64		SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08
+	Hs
		131125 PSDE_HUMAN (6-309): 7.58e-75: 234: 21.47		PCLO_HUMAN (76-1749): 3.04e-09: 64.9: 8.08