Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4
Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.98 | 1.00 | 0.991 |
The method score is based on:
Property | Details |
---|---|
Experiments | 25292214, 17996703, 17588522, 23146885, 17719543, 23287719, 25438670, 26949039, 17426036, 28069708, 26720344, 28470758, 28425671, 28475870, 30287686, 30254168, 30587574, 32334140, 31578285, 18287095 and 5 others
more... |
Identification Methods | enzymatic study, pull down, affinity chromatography technology |
Interaction Type | direct interaction, physical association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | HECT~HECT, HECT~WW, WW~WW |
Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000151 - ubiquitin ligase complex GO:0000785 - chromatin GO:0005634 - nucleus GO:0005737 - cytoplasm and 49 others more... |
Homologous interactions | 18 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024