HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36640330, 37005481
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~WW, WW~WW
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response and 1 others more... GO:0070064 - proline-rich region binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 504
+	Hs
		808226 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17
+	Hs
		808235 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73
+	Hs
		808278 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		808040 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26
+	Hs
		808276 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SMUF2_HUMAN (99-504): 4.95e-107: 337: 19.19
+	Hs
		1299600 NED4L_HUMAN (517-1319): 0: 934: 62.26		NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73
+	Hs
		808863 NED4L_HUMAN (517-1319): 0: 934: 62.26		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Mm
		93257 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		E9PXB7_MOUSE (8-504): 1.1e-114: 359: 19.11
+	Hs
		1299602 NED4L_HUMAN (517-1319): 0: 934: 62.26		MAGI1_HUMAN (69-305): 1.87e-39: 155: 18.32
+	Hs
		808720 HECW1_HUMAN (475-1317): 0: 726: 31.48		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		808736 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Sc
		765372 TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42		RSP5_YEAST (3-504): 1.79e-105: 334: 15.25
+	Hs
		1176337 HECW1_HUMAN (475-1317): 0: 726: 31.48		HECW1_HUMAN (2-222): 1.33e-24: 110: 14.96
+	Hs
		1176349 HECW1_HUMAN (475-1317): 0: 726: 31.48		HECW2_HUMAN (13-303): 1.56e-14: 79: 14.79
+	Sc
		975802 TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42		TOM1_YEAST (261-504): 2.18e-46: 176: 11.34
+	Hs
		1192247 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61
+	Pf
		1212177 Q8IB94_PLAF7 (939-1315): 5.84e-149: 503: 41.36		Q8IB94_PLAF7 (258-502): 4.68e-42: 163: 10.57
+	Hs
		125703 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		808915 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00