HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: SCNNG (P51170)
Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (ENaCG) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)
Gene: SCNN1G

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	10642508, 11244092, 12167593, 17013377, 11359767
Identification Methods	pull down, far western blotting, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1319 Hs			1 649
+	Hs
		808049 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SCNNB_HUMAN (7-633): 0: 603: 35.84
+	Hs
		739582 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Hs
		845991 NED4L_HUMAN (517-1319): 0: 934: 62.26		SCNNG_HUMAN (1-649): 0: 770: 100.00
+	Mm
		93286 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCNNG_MOUSE (1-649): 0: 739: 85.50
+	Hs
		845978 NED4L_HUMAN (517-1319): 0: 934: 62.26		SCNNB_HUMAN (7-633): 0: 603: 35.84
+	Hs
		739604 NED4L_HUMAN (517-1319): 0: 934: 62.26		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Mm
		1208291 NED4L_MOUSE (517-1319): 0: 936: 62.42		SCNNB_MOUSE (24-633): 0: 577: 35.27
+	Mm
		93272 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCNNA_MOUSE (24-611): 0: 579: 33.05
+	Mm
		93285 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCNNB_MOUSE (24-633): 0: 577: 35.27
+	Hs
		845975 HECW1_HUMAN (475-1317): 0: 726: 31.48		SCNNB_HUMAN (7-633): 0: 603: 35.84
+	Hs
		739596 HECW1_HUMAN (475-1317): 0: 726: 31.48		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Hs
		739597 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Rn
		739630 Q4V8H7_RAT (361-642): 9.73e-54: 206: 16.72		SCNNG_RAT (1-649): 0: 755: 86.62
+	Hs
		125257 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		SCNNG_HUMAN (1-649): 0: 770: 100.00
+	Hs
		739608 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Hs
		125256 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		SCNNB_HUMAN (7-633): 0: 603: 35.84
+	Hs
		125197 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Hs
		845977 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		SCNNB_HUMAN (7-633): 0: 603: 35.84
+	Hs
		739603 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		SCNNA_HUMAN (24-630): 0: 596: 33.39
+	Rn
		739625 NEDD4_RAT (433-678): 2.95e-16: 86.4: 16.23		SCNNA_RAT (24-611): 0: 578: 33.39