HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	26205498, 30287686, 19240029, 22350919
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 377
+	Hs
		874156 NED4L_HUMAN (517-1319): 0: 934: 62.26		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Hs
		874130 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Sc
		757016 TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42		RPN10_YEAST (1-224): 1.27e-98: 295: 49.15
+	Hs
		125283 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Hs
		874179 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Sc
		756928 RSP5_YEAST (388-669): 1.92e-30: 132: 14.41		RPN10_YEAST (1-224): 1.27e-98: 295: 49.15