HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	20086093, 23686771
Identification Methods	enzymatic study, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1319 Hs			1 1038
+	Hs
		337392 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Hs
		262241 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		ULK1_HUMAN (113-957): 7.3e-139: 446: 19.95
+	Hs
		808314 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		ERRFI_HUMAN (445-889): 3.2e-139: 427: 30.21
+	Hs
		808132 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17
+	Hs
		789045 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68
+	Hs
		433282 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		YES_HUMAN (1-400): 1.3e-128: 403: 29.93
+	Hs
		522850 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		412081 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		808126 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		FAK2_HUMAN (49-624): 1.48e-117: 387: 26.22
+	Hs
		808229 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		MARK4_HUMAN (68-785): 4.93e-117: 379: 17.13
+	Hs
		808060 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		EPHA5_HUMAN (109-396): 1.35e-108: 364: 33.33
+	Hs
		338105 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Hs
		992601 NED4L_HUMAN (517-1319): 0: 934: 62.26		ACK1_HUMAN (1-1038): 0: 805: 100.00
+	Hs
		992589 HECW1_HUMAN (475-1317): 0: 726: 31.48		ACK1_HUMAN (1-1038): 0: 805: 100.00
+	Hs
		337535 NED4L_HUMAN (517-1319): 0: 934: 62.26		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Hs
		262307 NED4L_HUMAN (517-1319): 0: 934: 62.26		ULK1_HUMAN (113-957): 7.3e-139: 446: 19.95
+	Hs
		789085 NED4L_HUMAN (517-1319): 0: 934: 62.26		ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68
+	Hs
		1052834 NED4L_HUMAN (517-1319): 0: 934: 62.26		FAK2_HUMAN (49-624): 1.48e-117: 387: 26.22
+	Hs
		338861 NED4L_HUMAN (517-1319): 0: 934: 62.26		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Hs
		337496 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03