HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19953087
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1319 Hs			1 487
+	Hs
		616684 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		KS6B1_HUMAN (20-440): 2.22e-130: 390: 20.68
+	Hs
		808324 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		AKT3_HUMAN (2-330): 8.44e-131: 389: 21.68
+	Hs
		808172 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		MARK2_HUMAN (6-486): 9.18e-123: 378: 20.68
+	Hs
		808341 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		STK24_HUMAN (19-367): 1.13e-121: 364: 45.20
+	Hs
		131554 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		STK25_HUMAN (14-327): 8.86e-120: 359: 48.74
+	Hs
		808304 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		STK26_HUMAN (25-390): 1.4e-119: 358: 43.82
+	Hs
		808315 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		TNIK_HUMAN (8-309): 2.1e-73: 254: 44.80
+	Hs
		808337 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		M4K5_HUMAN (20-318): 7.15e-75: 253: 44.30
+	Hs
		1299664 NED4L_HUMAN (517-1319): 0: 934: 62.26		AKT3_HUMAN (2-330): 8.44e-131: 389: 21.68
+	Hs
		1183099 NED4L_HUMAN (517-1319): 0: 934: 62.26		MARK2_HUMAN (6-486): 9.18e-123: 378: 20.68
+	Mm
		949373 NED4L_MOUSE (517-1319): 0: 936: 62.42		TNIK_MOUSE (8-309): 1.1e-73: 254: 44.80
+	Hs
		1233533 NED4L_HUMAN (517-1319): 0: 934: 62.26		MINK1_HUMAN (10-336): 5.97e-73: 252: 42.32
+	Mm
		93268 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		TNIK_MOUSE (8-309): 1.1e-73: 254: 44.80
+	Hs
		1023072 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		STK4_HUMAN (1-487): 7.89e-170: 489: 100.00
+	At
		1105338 UPL2_ARATH (837-1316): 9.11e-162: 540: 35.60		KIN10_ARATH (29-333): 2.48e-130: 389: 26.69
+	Mm
		949337 HUWE1_MOUSE (799-1317): 8.82e-169: 561: 35.25		TNIK_MOUSE (8-309): 1.1e-73: 254: 44.80
+	Hs
		1027416 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		STK3_HUMAN (1-487): 2.36e-147: 432: 72.47
+	Hs
		568765 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		KAPCA_HUMAN (14-319): 7.68e-123: 364: 26.90
+	Hs
		1183127 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		MARK2_HUMAN (6-486): 9.18e-123: 378: 20.68
+	Hs
		1336112 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		TNIK_HUMAN (8-309): 2.1e-73: 254: 44.80