HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: LAPM5 (Q13571)
Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein)
Gene: LAPTM5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	17116753, 19953087, 33961781, 15231748
Identification Methods	affinity chromatography technology, enzymatic study, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006622 - protein targeting to lysosome GO:0032991 - protein-containing complex GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 262
+	Hs
		808158 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		Q5TBB8_HUMAN (1-262): 2.03e-151: 424: 100.00
+	Hs
		1039512 NED4L_HUMAN (517-1319): 0: 934: 62.26		LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00
+	Hs
		1039515 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00
+	Hs
		125438 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00
+	Hs
		1039511 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00
+	Hs
		1039518 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00
+	Mm
		808355 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		LAPM5_MOUSE (1-262): 4.27e-144: 405: 79.01