HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: EREP1 (Q15884)
Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)
Gene: ENTREP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	26186194, 28514442, 33961781, 35044719
Identification Methods	affinity chromatography technology, unspecified method, phage display, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0031623 - receptor internalization
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 450
+	Hs
		808086 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		1079773 NED4L_HUMAN (517-1319): 0: 934: 62.26		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		946430 NED4L_HUMAN (517-1319): 0: 934: 62.26		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		1079753 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		946405 HECW1_HUMAN (475-1317): 0: 726: 31.48		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		1079783 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		125488 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		1079771 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		1079795 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		946437 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		946429 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		1259694 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53
+	Hs
		125597 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53
+	Hs
		946449 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38