HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19953087
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 788
+	Hs
		808229 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		MARK4_HUMAN (3-788): 0: 572: 48.20
+	Hs
		1183099 NED4L_HUMAN (517-1319): 0: 934: 62.26		MARK2_HUMAN (1-788): 0: 790: 100.00
+	At
		1105338 UPL2_ARATH (837-1316): 9.11e-162: 540: 35.60		KIN10_ARATH (37-452): 1.88e-154: 461: 35.71
+	Hs
		1183127 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		1349674 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		MARK1_HUMAN (3-788): 0: 644: 63.22
+	Sc
		419888 RSP5_YEAST (388-669): 1.92e-30: 132: 14.41		SNF1_YEAST (39-484): 9.23e-142: 433: 36.13
+	Hs
		883230 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		SIK1_HUMAN (31-679): 4.27e-140: 434: 32.98