HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: WBP2 (Q969T9)
WW domain-binding protein 2 (WBP-2)
Gene: WBP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.751

Property	Details
Experiments	19953087, 26371805, 28470758, 31578285, 33961781, 36446968, 16055720
Identification Methods	affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0050847 - progesterone receptor signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 261
+	Hs
		1282372 NED4L_HUMAN (517-1319): 0: 934: 62.26		WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00
+	Hs
		1192157 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00
+	Hs
		1282381 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00
+	Hs
		125630 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00
+	Hs
		1282371 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00
+	Mm
		808347 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		WBP2_MOUSE (1-261): 1.95e-70: 218: 96.94
+	Ce
		1090426 WWP1_CAEEL (609-799): 5.56e-29: 127: 27.04		Q18966_CAEEL (1-231): 7.38e-52: 170: 32.64