HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: PMEPA (Q969W9)
Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein)
Gene: PMEPA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	28218281, 29467225, 31605013, 33961781, 34638419, 36868334, 12907594
Identification Methods	two hybrid, affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 287
+	Hs
		170532 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88
+	Hs
		1282578 NED4L_HUMAN (517-1319): 0: 934: 62.26		PMEPA_HUMAN (1-287): 0: 521: 100.00
+	Hs
		170561 NED4L_HUMAN (517-1319): 0: 934: 62.26		LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88
+	Hs
		170549 HECW1_HUMAN (475-1317): 0: 726: 31.48		LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88
+	Hs
		170566 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88
+	Hs
		125004 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88
+	Mm
		57497 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		A2APF4_MOUSE (5-287): 7.68e-160: 447: 88.69
+	Hs
		170560 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88
+	Hs
		170568 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88
+	Mm
		808374 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		PMEPA_MOUSE (27-287): 3.8e-141: 399: 88.51
+	Hs
		170569 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88
+	Hs
		170573 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88