HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: WBP1 (Q96G27)
WW domain-binding protein 1 (WBP-1)
Gene: WBP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.50	0.609

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 269
+	Hs
		1291859 NED4L_HUMAN (517-1319): 0: 934: 62.26		WBP1_HUMAN (1-269): 2.82e-160: 447: 100.00
+	Mm
		93278 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		WBP1L_MOUSE (22-230): 2.32e-95: 285: 38.24
+	Hs
		1291863 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		WBP1_HUMAN (1-269): 2.82e-160: 447: 100.00
+	Hs
		125643 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		WBP1_HUMAN (1-269): 2.82e-160: 447: 100.00
+	Hs
		1291858 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		WBP1_HUMAN (1-269): 2.82e-160: 447: 100.00
+	Hs
		1291869 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		WBP1_HUMAN (1-269): 2.82e-160: 447: 100.00
+	Mm
		1206454 WWP1_MOUSE (388-642): 1.24e-53: 206: 16.91		WBP1L_MOUSE (22-230): 2.32e-95: 285: 38.24
+	Mm
		1206455 ITCH_MOUSE (433-653): 3.68e-52: 200: 16.33		WBP1L_MOUSE (22-230): 2.32e-95: 285: 38.24
+	Mm
		808346 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		WBP1_MOUSE (1-269): 3.03e-142: 403: 74.67
+	Mm
		1206456 WWP2_MOUSE (381-669): 4.39e-33: 141: 13.37		WBP1L_MOUSE (22-230): 2.32e-95: 285: 38.24