HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: MLP3A (Q9H492)
Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha)
Gene: MAP1LC3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	29251248, 20562859
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 121
+	Hs
		808068 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		GBRL2_HUMAN (7-121): 5.54e-54: 166: 41.74
+	Hs
		306025 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		GBRAP_HUMAN (7-121): 2.99e-52: 161: 30.44
+	Hs
		808261 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		MLP3B_HUMAN (1-121): 6.65e-52: 161: 81.82
+	Hs
		808254 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		MLP3C_HUMAN (1-120): 5.63e-51: 159: 59.17
+	Hs
		808265 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		GBRL1_HUMAN (3-120): 5.97e-51: 158: 33.05
+	Hs
		1299634 NED4L_HUMAN (517-1319): 0: 934: 62.26		MLP3A_HUMAN (1-121): 4.19e-54: 167: 100.00
+	Hs
		1192207 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		MLP3B_HUMAN (1-121): 6.65e-52: 161: 81.82
+	Sc
		745993 RSP5_YEAST (388-669): 1.92e-30: 132: 14.41		ATG8_YEAST (3-120): 2.38e-54: 167: 35.59
+	Ce
		1095399 WWP1_CAEEL (609-799): 5.56e-29: 127: 27.04		LGG2_CAEEL (6-120): 4.95e-44: 141: 59.13