HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: SAV1 (Q9H4B6)
Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45)
Gene: SAV1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	25692647
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HECT~WW, WW~WW
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 383
+	Hs
		808276 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SMUF2_HUMAN (119-381): 4.3e-68: 230: 20.14
+	Hs
		808278 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SMUF1_HUMAN (147-381): 2.43e-59: 206: 18.32
+	Hs
		808226 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		ITCH_HUMAN (41-315): 8.61e-36: 141: 19.36
+	Hs
		808040 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		NEDD4_HUMAN (42-307): 3.99e-20: 94.4: 14.84
+	Hs
		808235 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		NED4L_HUMAN (151-312): 1.2e-09: 62.1: 18.07
+	Hs
		1299602 NED4L_HUMAN (517-1319): 0: 934: 62.26		MAGI1_HUMAN (170-306): 1.6e-29: 122: 26.55
+	Hs
		1299600 NED4L_HUMAN (517-1319): 0: 934: 62.26		NED4L_HUMAN (151-312): 1.2e-09: 62.1: 18.07
+	Mm
		93257 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		E9PXB7_MOUSE (65-349): 9.47e-14: 74.8: 14.77
+	Hs
		1176349 HECW1_HUMAN (475-1317): 0: 726: 31.48		HECW2_HUMAN (2-325): 2.21e-42: 160: 17.63
+	Hs
		1176337 HECW1_HUMAN (475-1317): 0: 726: 31.48		HECW1_HUMAN (9-380): 1.87e-12: 70.9: 13.72
+	Hs
		1192247 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		WWOX_HUMAN (198-282): 3.98e-30: 121: 31.87
+	Sc
		765372 TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42		RSP5_YEAST (65-234): 3.78e-13: 72.8: 17.06
+	Dm
		1374788 SUDX_DROME (446-646): 7.9e-40: 162: 16.81		NEDD4_DROME (13-382): 1.46e-50: 184: 12.88
+	Hs
		1294856 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		ITCH_HUMAN (41-315): 8.61e-36: 141: 19.36
+	Hs
		125703 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		WWP2_HUMAN (45-319): 1.29e-33: 134: 15.85
+	Hs
		1327908 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		WWP1_HUMAN (3-322): 5.63e-29: 120: 15.12
+	Hs
		125652 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		ITCH_HUMAN (41-315): 8.61e-36: 141: 19.36
+	Hs
		124986 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		WWP2_HUMAN (45-319): 1.29e-33: 134: 15.85