HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25692647, 34586722
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1319 Hs			1 1088
+	Hs
		325655 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		681731 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		808324 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		AKT3_HUMAN (532-1043): 3.66e-141: 435: 22.01
+	Hs
		116984 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SGK1_HUMAN (608-1042): 1.07e-131: 408: 28.51
+	Hs
		808054 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		1299664 NED4L_HUMAN (517-1319): 0: 934: 62.26		AKT3_HUMAN (532-1043): 3.66e-141: 435: 22.01
+	Hs
		681988 NED4L_HUMAN (517-1319): 0: 934: 62.26		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Mm
		1208292 NED4L_MOUSE (517-1319): 0: 936: 62.42		SGK1_MOUSE (608-1042): 1.31e-131: 408: 28.73
+	Hs
		117024 NED4L_HUMAN (517-1319): 0: 934: 62.26		SGK1_HUMAN (608-1042): 1.07e-131: 408: 28.51
+	Mm
		93288 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SGK1_MOUSE (608-1042): 1.31e-131: 408: 28.73
+	Hs
		325886 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		125071 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325853 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325894 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325898 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		1336122 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		ST38L_HUMAN (592-1051): 1.3e-146: 448: 41.30
+	Hs
		1069657 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Hs
		568765 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Dm
		1360297 SMUF1_DROME (382-721): 5.2e-13: 76: 12.96		WARTS_DROME (167-1039): 7.21e-137: 443: 39.71
+	Hs
		1035209 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77