HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: TNIK (Q9UKE5)
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	28405688, 20159449
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048814 - regulation of dendrite morphogenesis GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1319 Hs			1 1360
+	Hs
		808054 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		808229 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		MARK4_HUMAN (7-748): 2.35e-123: 403: 18.00
+	Hs
		808110 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		STK4_HUMAN (5-482): 7.72e-121: 387: 33.06
+	Hs
		131554 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		STK25_HUMAN (20-410): 8.77e-113: 362: 37.91
+	Hs
		808304 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		STK26_HUMAN (16-400): 7.78e-113: 362: 38.27
+	Hs
		808341 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		STK24_HUMAN (20-340): 2.15e-111: 359: 43.03
+	Hs
		808337 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		M4K5_HUMAN (19-373): 7.89e-73: 263: 40.38
+	Mm
		949373 NED4L_MOUSE (517-1319): 0: 936: 62.42		TNIK_MOUSE (1-1360): 0: 1208: 96.10
+	Mm
		93268 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		TNIK_MOUSE (1-1360): 0: 1208: 96.10
+	Hs
		1233533 NED4L_HUMAN (517-1319): 0: 934: 62.26		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Mm
		949337 HUWE1_MOUSE (799-1317): 8.82e-169: 561: 35.25		TNIK_MOUSE (1-1360): 0: 1208: 96.10
+	Mm
		93277 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		TAOK2_MOUSE (1-858): 2.53e-132: 440: 22.14
+	Hs
		1336112 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		TNIK_HUMAN (1-1360): 0: 1235: 100.00
+	Mm
		808345 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		TNIK_MOUSE (1-1360): 0: 1208: 96.10
+	Hs
		1023072 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		STK4_HUMAN (5-482): 7.72e-121: 387: 33.06
+	At
		1105338 UPL2_ARATH (837-1316): 9.11e-162: 540: 35.60		KIN10_ARATH (19-435): 2.66e-126: 402: 20.43
+	Hs
		1027416 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		STK3_HUMAN (4-485): 1.79e-115: 372: 29.28
+	Sc
		419888 RSP5_YEAST (388-669): 1.92e-30: 132: 14.41		SNF1_YEAST (23-474): 8.57e-108: 356: 22.34
+	Hs
		1329544 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		TAOK3_HUMAN (14-514): 8.99e-109: 367: 29.92
+	Hs
		1336133 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		M4K5_HUMAN (19-373): 7.89e-73: 263: 40.38