HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: SCN8A (Q9UQD0)
Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)
Gene: SCN8A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20530479
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1319 Hs			1 1980
+	Hs
		723839 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SCN1A_HUMAN (1-1968): 0: 1865: 72.73
+	Hs
		808128 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SCN5A_HUMAN (3-1953): 0: 1782: 61.04
+	Hs
		808340 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SCNAA_HUMAN (6-1976): 0: 1697: 53.59
+	Mm
		93284 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCN8A_MOUSE (1-1980): 0: 2014: 98.23
+	Mm
		69865 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCN2A_MOUSE (1-1979): 0: 1928: 72.95
+	Mm
		93274 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCN9A_MOUSE (4-1974): 0: 1874: 68.48
+	Hs
		1055040 NED4L_HUMAN (517-1319): 0: 934: 62.26		SCN5A_HUMAN (3-1953): 0: 1782: 61.04
+	Mm
		93283 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCN5A_MOUSE (3-1955): 0: 1783: 61.03
+	Mm
		69867 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		SCN2A_MOUSE (1-1979): 0: 1928: 72.95
+	Hs
		1079738 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		SCN9A_HUMAN (4-1979): 0: 1879: 69.66
+	Hs
		723851 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		SCN1A_HUMAN (1-1968): 0: 1865: 72.73
+	Mm
		808358 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		SCN9A_MOUSE (4-1974): 0: 1874: 68.48
+	Hs
		125457 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		SCN5A_HUMAN (3-1953): 0: 1782: 61.04
+	Hs
		1055045 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		SCN5A_HUMAN (3-1953): 0: 1782: 61.04
+	Mm
		93270 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		Q3UF73_MOUSE (1-205): 1.67e-96: 311: 73.66
+	Mm
		93276 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCNAA_MOUSE (1491-1980): 2.93e-35: 150: 16.60
+	Hs
		1047217 NED4L_HUMAN (517-1319): 0: 934: 62.26		CAC1C_HUMAN (20-277): 1.6e-15: 85.3: 16.97
+	Hs
		132322 HECW1_HUMAN (475-1317): 0: 726: 31.48		CAC1A_HUMAN (20-701): 3.85e-26: 120: 13.60
+	Mm
		808349 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		Q3UF73_MOUSE (1-205): 1.67e-96: 311: 73.66
+	Hs
		125445 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		CAC1C_HUMAN (20-277): 1.6e-15: 85.3: 16.97