HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16055720
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 456
+	Hs
		1192274 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1192273 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		975814 TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		975876 TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42		RUVB2_YEAST (5-455): 0: 627: 41.72
+	Hs
		125801 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		125799 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		RUVB2_HUMAN (2-455): 0: 651: 42.76