HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: AMOL2 (Q9Y2J4)
Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)
Gene: AMOTL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 779
+	Hs
		808151 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		808183 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		AMOL1_HUMAN (1-766): 4.56e-42: 167: 40.22
+	Hs
		1119034 NED4L_HUMAN (517-1319): 0: 934: 62.26		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		1222263 NED4L_HUMAN (517-1319): 0: 934: 62.26		AMOL1_HUMAN (1-766): 4.56e-42: 167: 40.22
+	Hs
		724896 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		MYH9_HUMAN (16-773): 4.81e-28: 123: 9.57
+	Hs
		1119052 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		1327936 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		AMOL2_HUMAN (1-779): 1.36e-71: 251: 100.00
+	Hs
		125503 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		125805 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		AMOL2_HUMAN (1-779): 1.36e-71: 251: 100.00
+	Hs
		1119026 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		1222267 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		AMOL1_HUMAN (1-766): 4.56e-42: 167: 40.22
+	Hs
		125569 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		AMOL1_HUMAN (1-766): 4.56e-42: 167: 40.22
+	Hs
		1119083 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		1350508 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		AMOL2_HUMAN (1-779): 1.36e-71: 251: 100.00
+	Hs
		1078893 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		ITSN1_HUMAN (136-766): 1.5e-36: 150: 11.46
+	Hs
		1222275 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		AMOL1_HUMAN (1-766): 4.56e-42: 167: 40.22
+	Hs
		551845 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		DESP_HUMAN (16-454): 7.49e-11: 68.1: 12.02