HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: RNF11 (Q9Y3C5)
RING finger protein 11
Gene: RNF11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	35044719, 19953087, 28292929, 31985874, 20676133, 15231748
Identification Methods	unspecified method, enzymatic study, affinity chromatography technology, two hybrid, pull down, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1319 Hs			1 154
+	Hs
		1299666 NED4L_HUMAN (517-1319): 0: 934: 62.26		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1255980 NED4L_HUMAN (517-1319): 0: 934: 62.26		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		1192280 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Mm
		1208051 ITCH_MOUSE (433-653): 3.68e-52: 200: 16.33		RNF11_MOUSE (1-154): 1.27e-42: 140: 99.35
+	Hs
		1327938 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		125810 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		125596 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		1294890 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1334883 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1336128 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1240725 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		RN149_HUMAN (54-147): 1.09e-25: 102: 34.04
+	Hs
		1255979 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Mm
		808380 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		RNF11_MOUSE (1-154): 1.27e-42: 140: 99.35
+	Hs
		1334874 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29