HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: SCNAA (Q9Y5Y9)
Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)
Gene: SCN10A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	35044719
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0034765 - regulation of monoatomic ion transmembrane transport GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1319 Hs			1 1956
+	Hs
		723839 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SCN1A_HUMAN (5-1942): 0: 1829: 53.28
+	Hs
		808128 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SCN5A_HUMAN (5-1955): 0: 1817: 61.08
+	Mm
		93276 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCNAA_MOUSE (1-1956): 0: 2005: 82.28
+	Mm
		69865 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCN2A_MOUSE (5-1950): 0: 1867: 53.94
+	Hs
		1055040 NED4L_HUMAN (517-1319): 0: 934: 62.26		SCN5A_HUMAN (5-1955): 0: 1817: 61.08
+	Mm
		93274 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCN9A_MOUSE (5-1947): 0: 1827: 53.85
+	Mm
		93283 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCN5A_MOUSE (5-1955): 0: 1821: 61.00
+	Hs
		808322 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		SCN8A_HUMAN (624-1086): 1.67e-45: 183: 18.08
+	Mm
		808363 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		SCNAA_MOUSE (1-1956): 0: 2005: 82.28
+	Hs
		125457 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		SCN5A_HUMAN (5-1955): 0: 1817: 61.08
+	Hs
		1079738 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		SCN9A_HUMAN (5-1950): 0: 1833: 53.45
+	Hs
		723851 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		SCN1A_HUMAN (5-1942): 0: 1829: 53.28
+	Mm
		69867 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		SCN2A_MOUSE (5-1950): 0: 1867: 53.94
+	Hs
		1055045 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		SCN5A_HUMAN (5-1955): 0: 1817: 61.08
+	Mm
		808358 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		SCN9A_MOUSE (5-1947): 0: 1827: 53.85
+	Mm
		808378 NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29		SCN5A_MOUSE (5-1955): 0: 1821: 61.00
+	Mm
		93284 E9PXB7_MOUSE (539-1319): 0: 907: 62.80		SCN8A_MOUSE (624-1086): 2.17e-45: 183: 18.08
+	Hs
		1047217 NED4L_HUMAN (517-1319): 0: 934: 62.26		CAC1C_HUMAN (33-518): 5.71e-19: 96.9: 14.18
+	Hs
		132322 HECW1_HUMAN (475-1317): 0: 726: 31.48		CAC1A_HUMAN (109-643): 8.04e-21: 103: 15.66
+	Hs
		125445 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		CAC1C_HUMAN (33-518): 5.71e-19: 96.9: 14.18