HitPredict

Interactor 1: NEDD4 (P46935)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: SCN5A (Q9JJV9)
Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (mH1)
Gene: SCN5A

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15123669
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 887 Mm			1 2019
+	Hs
		1055040 NED4L_HUMAN (70-887): 0: 777: 55.91		SCN5A_HUMAN (1-2019): 0: 2031: 94.30
+	Mm
		69867 NEDD4_MOUSE (1-887): 0: 935: 100.00		SCN2A_MOUSE (3-2003): 0: 1872: 61.18
+	Mm
		808363 NEDD4_MOUSE (1-887): 0: 935: 100.00		SCNAA_MOUSE (5-2014): 0: 1842: 60.96
+	Mm
		808358 NEDD4_MOUSE (1-887): 0: 935: 100.00		SCN9A_MOUSE (2-2006): 0: 1839: 60.31
+	Hs
		808128 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCN5A_HUMAN (1-2019): 0: 2031: 94.30
+	Hs
		1055045 SMUF2_HUMAN (79-883): 0: 678: 34.20		SCN5A_HUMAN (1-2019): 0: 2031: 94.30
+	Hs
		125457 WWP2_HUMAN (75-884): 0: 675: 33.18		SCN5A_HUMAN (1-2019): 0: 2031: 94.30
+	Mm
		808381 NEDD4_MOUSE (1-887): 0: 935: 100.00		SCN8A_MOUSE (2-2003): 0: 1745: 59.81
+	Hs
		723839 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCN1A_HUMAN (4-2003): 0: 1820: 60.57
+	Mm
		69865 E9PXB7_MOUSE (172-887): 0: 665: 56.84		SCN2A_MOUSE (3-2003): 0: 1872: 61.18
+	Hs
		1079738 SMUF2_HUMAN (79-883): 0: 678: 34.20		SCN9A_HUMAN (2-2005): 0: 1834: 59.87
+	Mm
		93276 E9PXB7_MOUSE (172-887): 0: 665: 56.84		SCNAA_MOUSE (5-2014): 0: 1842: 60.96
+	Hs
		808340 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCNAA_HUMAN (5-2007): 0: 1780: 61.77
+	Mm
		93274 E9PXB7_MOUSE (172-887): 0: 665: 56.84		SCN9A_MOUSE (2-2006): 0: 1839: 60.31
+	Hs
		723851 SMUF2_HUMAN (79-883): 0: 678: 34.20		SCN1A_HUMAN (4-2003): 0: 1820: 60.57
+	Hs
		808322 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCN8A_HUMAN (2-2003): 0: 1739: 59.51
+	Mm
		808349 NEDD4_MOUSE (1-887): 0: 935: 100.00		Q3UF73_MOUSE (4-204): 2.88e-86: 282: 68.66
+	Mm
		93270 E9PXB7_MOUSE (172-887): 0: 665: 56.84		Q3UF73_MOUSE (4-204): 2.88e-86: 282: 68.66
+	Hs
		1047217 NED4L_HUMAN (70-887): 0: 777: 55.91		CAC1C_HUMAN (21-553): 3.82e-23: 110: 15.79
+	Hs
		125445 WWP2_HUMAN (75-884): 0: 675: 33.18		CAC1C_HUMAN (21-553): 3.82e-23: 110: 15.79