HitPredict

Interactor 1: NEDD4 (P46935)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: SCNNB (Q9WU38)
Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Gene: Scnn1b

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	10212229, 17544362, 15123669
Identification Methods	far western blotting, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006814 - sodium ion transport GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 887 Mm			1 638
+	Rn
		739628 NEDD4_RAT (5-887): 0: 914: 94.70		SCNNB_RAT (1-638): 0: 737: 96.71
+	Mm
		808383 NEDD4_MOUSE (1-887): 0: 935: 100.00		SCNNG_MOUSE (16-623): 0: 589: 35.71
+	Mm
		808356 NEDD4_MOUSE (1-887): 0: 935: 100.00		SCNNA_MOUSE (21-637): 0: 585: 32.44
+	Rn
		739631 NEDD4_RAT (5-887): 0: 914: 94.70		SCNNG_RAT (16-623): 0: 596: 36.00
+	Mm
		1208291 NED4L_MOUSE (39-887): 0: 781: 54.22		SCNNB_MOUSE (1-638): 0: 727: 100.00
+	Rn
		739625 NEDD4_RAT (5-887): 0: 914: 94.70		SCNNA_RAT (21-638): 0: 585: 32.75
+	Hs
		845978 NED4L_HUMAN (70-887): 0: 777: 55.91		SCNNB_HUMAN (1-638): 0: 719: 83.91
+	Hs
		808049 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCNNB_HUMAN (1-638): 0: 719: 83.91
+	Hs
		845977 ITCH_HUMAN (67-884): 0: 703: 31.32		SCNNB_HUMAN (1-638): 0: 719: 83.91
+	Hs
		125256 WWP2_HUMAN (75-884): 0: 675: 33.18		SCNNB_HUMAN (1-638): 0: 719: 83.91
+	Hs
		739604 NED4L_HUMAN (70-887): 0: 777: 55.91		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Hs
		845991 NED4L_HUMAN (70-887): 0: 777: 55.91		SCNNG_HUMAN (19-624): 0: 591: 35.43
+	Hs
		739582 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Hs
		808050 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCNNG_HUMAN (19-624): 0: 591: 35.43
+	Hs
		739603 ITCH_HUMAN (67-884): 0: 703: 31.32		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Rn
		739630 Q4V8H7_RAT (65-884): 0: 693: 32.04		SCNNG_RAT (16-623): 0: 596: 36.00
+	Hs
		739608 WWP1_HUMAN (65-884): 0: 682: 30.86		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Hs
		125197 WWP2_HUMAN (75-884): 0: 675: 33.18		SCNNA_HUMAN (21-625): 0: 591: 32.25
+	Hs
		125257 WWP2_HUMAN (75-884): 0: 675: 33.18		SCNNG_HUMAN (19-624): 0: 591: 35.43
+	Mm
		93272 E9PXB7_MOUSE (172-887): 0: 665: 56.84		SCNNA_MOUSE (21-637): 0: 585: 32.44