HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	27684187, 38280479, 38223760
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030054 - cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 1748
+	Hs
		125403 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		125577 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67
+	Hs
		1232500 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67
+	Hs
		808764 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67
+	Mm
		809081 YAP1_MOUSE (35-504): 1.41e-115: 351: 91.70		PALS1_MOUSE (299-806): 3.42e-84: 293: 16.43
+	Hs
		1271021 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		DLG3_HUMAN (21-427): 4.69e-51: 197: 17.51
+	Mm
		93267 E9PXB7_MOUSE (8-504): 1.1e-114: 359: 19.11		DLG3_MOUSE (21-396): 1.29e-48: 190: 18.65
+	Mm
		808344 NEDD4_MOUSE (28-504): 2.4e-113: 357: 16.98		DLG3_MOUSE (21-396): 1.29e-48: 190: 18.65
+	Hs
		125592 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77
+	Mm
		1143429 NED4L_MOUSE (4-504): 5.54e-115: 364: 19.73		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Mm
		93273 E9PXB7_MOUSE (8-504): 1.1e-114: 359: 19.11		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Hs
		808559 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		1246432 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77
+	Hs
		808786 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77
+	Hs
		280032 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		MPDZ_HUMAN (31-489): 8.85e-18: 92.6: 13.61
+	Hs
		808565 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Mm
		809075 YAP1_MOUSE (35-504): 1.41e-115: 351: 91.70		INADL_MOUSE (60-508): 1.05e-18: 95.7: 20.29
+	Hs
		808779 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		KMT2C_HUMAN (872-1617): 7.83e-14: 79.8: 13.75
+	Hs
		1327931 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98
+	Hs
		808986 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98