HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: ASPP2 (Q13625)
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Gene: TP53BP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.760

Property	Details
Experiments	25436413, 11278422, 24366813, 10358088, 25796446, 27684187, 30472188, 31636332, 26933062, 38280479, 24255178, 25751139
Identification Methods	affinity chromatography technology, two hybrid, unspecified method, far western blotting, pull down, proximity labelling technology, tandem affinity purification, two hybrid array, peptide array, anti tag coimmunoprecipitation and 1 others more... two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030054 - cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 1128
+	Hs
		125441 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		1043731 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		808118 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		125654 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38
+	Hs
		808103 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90
+	Hs
		1043750 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		1296373 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38
+	Hs
		518833 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		TPR_HUMAN (62-894): 9.75e-55: 211: 13.79
+	Hs
		125054 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		PSD10_HUMAN (988-1128): 3e-43: 159: 16.77
+	Mm
		966330 ITCH_MOUSE (2-504): 2.6e-119: 372: 14.36		NOTC1_MOUSE (608-1051): 1.86e-45: 182: 14.09
+	Hs
		125583 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ANR44_HUMAN (962-1128): 1.48e-36: 151: 19.16
+	Hs
		276153 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PSD10_HUMAN (988-1128): 3e-43: 159: 16.77
+	Hs
		1336115 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		ANR50_HUMAN (836-995): 6.95e-17: 88.7: 16.88
+	Hs
		1336100 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		DAPLE_HUMAN (33-349): 6.45e-16: 85.6: 16.36
+	Hs
		161328 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89
+	Dm
		1376443 Q9W2L2_DROME (1-267): 6.8e-44: 168: 21.01		Q9W2J2_DROME (126-1123): 2.51e-75: 272: 27.13
+	Hs
		808779 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		KMT2C_HUMAN (222-886): 1.84e-09: 64.7: 11.45
+	Hs
		1219842 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		ANKH1_HUMAN (922-1013): 2.42e-20: 100: 30.44
+	Hs
		862101 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		DAPK1_HUMAN (791-1011): 1.31e-20: 100: 13.12
+	Hs
		161448 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89