HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: WWC2 (Q6AWC2)
Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)
Gene: WWC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30472188
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WW~WW
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 1192
+	Hs
		1299602 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		MAGI1_HUMAN (1-300): 2.32e-62: 236: 18.94
+	Hs
		1294877 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		WWOX_HUMAN (5-198): 5.51e-47: 176: 21.11
+	Hs
		125703 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		WWP1_HUMAN (6-136): 2.07e-35: 148: 23.78
+	Hs
		125652 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ITCH_HUMAN (7-143): 1.17e-33: 142: 24.66
+	Hs
		124986 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84
+	Hs
		1294856 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		WWP1_HUMAN (6-136): 2.07e-35: 148: 23.78
+	Hs
		1294834 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		ITCH_HUMAN (7-143): 1.17e-33: 142: 24.66
+	Hs
		1334870 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		SMUF2_HUMAN (9-163): 1.79e-22: 106: 15.61
+	Hs
		125235 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Hs
		808226 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Hs
		1336083 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		SMUF1_HUMAN (40-194): 1.56e-14: 80.8: 16.49
+	Hs
		808850 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Hs
		808235 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Hs
		808278 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Hs
		808863 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Hs
		808947 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Hs
		1299600 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		NED4L_HUMAN (1-141): 6.93e-09: 62.3: 18.37
+	Hs
		808915 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25