HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: CRTC3 (Q6UUV7)
CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)
Gene: CRTC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	35044719
Identification Methods	unspecified method, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 619
+	Hs
		1164911 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		CRTC3_HUMAN (1-619): 3.08e-76: 256: 100.00
+	Hs
		808152 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		CRTC2_HUMAN (2-619): 2.13e-52: 193: 35.62
+	Hs
		125405 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ACK1_HUMAN (84-451): 3.81e-22: 103: 12.77
+	Hs
		554367 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		MUC1_HUMAN (80-590): 1.71e-28: 123: 10.76
+	Hs
		992601 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		ACK1_HUMAN (84-451): 3.81e-22: 103: 12.77
+	Hs
		992607 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		ACK1_HUMAN (84-451): 3.81e-22: 103: 12.77
+	Hs
		125061 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SC24D_HUMAN (241-509): 9.65e-10: 63.9: 13.92
+	Hs
		125274 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SC24C_HUMAN (129-438): 4.01e-09: 61.9: 13.18
+	Hs
		125277 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ATN1_HUMAN (81-565): 8.32e-09: 60.9: 9.28
+	Hs
		808104 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		ACK1_HUMAN (84-451): 3.81e-22: 103: 12.77
+	Hs
		869511 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		ATN1_HUMAN (81-565): 8.32e-09: 60.9: 9.28
+	Hs
		808779 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		KMT2C_HUMAN (70-553): 1.1e-11: 70.5: 9.96
+	Hs
		869535 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		ATN1_HUMAN (81-565): 8.32e-09: 60.9: 9.28
+	Hs
		808424 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		ATN1_HUMAN (81-565): 8.32e-09: 60.9: 9.28
+	Hs
		808716 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		SRCAP_HUMAN (88-586): 9.2e-09: 60.9: 10.62
+	Hs
		161713 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		GAK_HUMAN (248-528): 1.01e-28: 124: 15.52
+	Hs
		203253 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SYNJ1_HUMAN (57-447): 1.18e-10: 67: 9.61
+	Hs
		1170084 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SRCAP_HUMAN (88-586): 9.2e-09: 60.9: 10.62
+	Hs
		992585 MAGI3_HUMAN (69-270): 5.85e-40: 156: 21.64		ACK1_HUMAN (84-451): 3.81e-22: 103: 12.77
+	Sc
		758550 TOM1_YEAST (261-504): 2.18e-46: 176: 11.34		SEC31_YEAST (72-452): 2.34e-11: 69.3: 8.01