HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: CPSF7 (Q8N684)
Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)
Gene: CPSF7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30472188
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 471
+	Hs
		125581 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		CPSF7_HUMAN (1-456): 1.39e-122: 367: 100.00
+	Hs
		1235773 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		CPSF7_HUMAN (1-456): 1.39e-122: 367: 100.00
+	Hs
		1235798 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		CPSF7_HUMAN (1-456): 1.39e-122: 367: 100.00
+	Hs
		125492 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		1084573 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		1084629 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		1084614 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		808655 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		808144 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		1235824 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		CPSF7_HUMAN (1-456): 1.39e-122: 367: 100.00
+	Hs
		125430 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Hs
		125122 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		516643 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		808925 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PABP3_HUMAN (83-184): 4.77e-13: 73.4: 19.61
+	Hs
		516402 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		1084647 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Dm
		1115151 YAP1_DROME (52-268): 1.16e-44: 163: 29.25		CPSF6_DROME (13-409): 3.19e-41: 157: 29.78
+	Sc
		376913 TOM1_YEAST (261-504): 2.18e-46: 176: 11.34		PABP_YEAST (83-159): 2.45e-16: 83.4: 24.68
+	Hs
		1031480 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Hs
		516721 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36