HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: SMRC2 (Q8TAQ2)
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)
Gene: SMARCC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 1214
+	Hs
		125594 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SMRC2_HUMAN (1-1203): 0: 992: 100.00
+	Hs
		1251602 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		SMRC2_HUMAN (1-1203): 0: 992: 100.00
+	Hs
		125620 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Mm
		956831 WWP2_MOUSE (1-504): 1.16e-129: 399: 15.68		SMRC1_MOUSE (4-1028): 0: 952: 64.13
+	Hs
		1272920 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		808818 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		808208 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		1272935 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		125001 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Hs
		160143 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Hs
		160160 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Hs
		232038 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		159925 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Hs
		261434 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		NCOR1_HUMAN (597-1154): 8.84e-32: 137: 10.86
+	Hs
		125274 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SC24C_HUMAN (1005-1213): 5.27e-13: 75.8: 19.28
+	Hs
		125061 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SC24D_HUMAN (951-1204): 5.56e-13: 75.7: 25.44
+	Hs
		808779 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57
+	Hs
		261586 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		NCOR1_HUMAN (597-1154): 8.84e-32: 137: 10.86
+	Hs
		1326738 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		PTN23_HUMAN (768-1213): 4.36e-30: 132: 19.59
+	Hs
		203253 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SYNJ1_HUMAN (645-1129): 3.34e-11: 70.1: 9.36