HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: SMCE1 (Q969G3)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)
Gene: SMARCE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30472188, 38280479
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:1902459 - positive regulation of stem cell population maintenance
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 411
+	Hs
		125626 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Hs
		1281223 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Hs
		125141 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		UBF1_HUMAN (55-380): 1.54e-40: 155: 14.99
+	Hs
		125378 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		TFAM_HUMAN (64-259): 2.52e-29: 116: 19.19
+	Hs
		125410 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SSRP1_HUMAN (61-135): 1.2e-21: 99.3: 25.33
+	Hs
		297469 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		TOX4_HUMAN (10-144): 2.28e-27: 116: 24.29
+	Hs
		996907 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		SSRP1_HUMAN (61-135): 1.2e-21: 99.3: 25.33
+	Hs
		808546 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		SSRP1_HUMAN (61-135): 1.2e-21: 99.3: 25.33
+	Hs
		1281239 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Hs
		1281255 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		SMCE1_HUMAN (1-411): 6.03e-79: 251: 100.00
+	Hs
		297545 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		TOX4_HUMAN (10-144): 2.28e-27: 116: 24.29
+	Dm
		1115166 YAP1_DROME (52-268): 1.16e-44: 163: 29.25		Q9W384_DROME (72-350): 3.45e-35: 139: 46.10
+	Hs
		996887 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SSRP1_HUMAN (61-135): 1.2e-21: 99.3: 25.33
+	Hs
		1342342 HECW2_HUMAN (13-303): 1.56e-14: 79: 14.79		HM20A_HUMAN (3-308): 1.64e-39: 146: 16.08